Muscle extract of Arothron immaculatus regulates the blood glucose level and the antioxidant system in high-fat diet and streptozotocin induced diabetic rats
| Autor: | T. Sivasudha, Ganesan Arun, Rajendran Rajaram, Balázs Gulyás, Govindaraju Archunan, Nambirajan Gayathri, Parasuraman Padmanabhan, K. Kaleshkumar |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Blood Glucose
Male Antioxidant medicine.medical_treatment Arothron Pharmacology Diet High-Fat 01 natural sciences Biochemistry Antioxidants Diabetes Mellitus Experimental Docosanol Diabetes mellitus Drug Discovery medicine Animals Hypoglycemic Agents Insulin Rats Wistar Muscle Skeletal Molecular Biology Metoprolol biology Tetraodontiformes 010405 organic chemistry Chemistry Organic Chemistry Streptozotocin biology.organism_classification medicine.disease In vitro Rats 0104 chemical sciences 010404 medicinal & biomolecular chemistry Docosahexaenoic acid medicine.drug |
| Zdroj: | Bioorganic Chemistry. 90:103072 |
| ISSN: | 0045-2068 |
| DOI: | 10.1016/j.bioorg.2019.103072 |
| Popis: | In the present study pufferfish, Arothron immaculatus muscle methanol extract (AIME) was used to evaluate the antidiabetic activity against the high-fat diet (HFD) in streptozotocin (STZ) induced diabetic rat models. Initially, the In vitro antioxidant activity of the different muscle extract was evaluated which showed that AIME has higher efficiency to scavenge the free radicals. The animal study results revealed that the AIME could decrease the blood glucose level after 14 days of oral treatment and recover the animal from the severe progression of the disease. The LC-ESI/MS analysis of AIME extract revealed the presence of compounds such as docosahexaenoic acid, adrenic acid, docosanol, codeine and metoprolol. Among these compounds, docosahexaenoic acid, adrenic acid and docosanol are reported for its antidiabetic studies. Hence, the muscle is recommended to consume by humans as natural food in order to overcome the development of diabetes. This is the first study on the muscle extract of marine pufferfish which is used as antidiabetic agent to treat the diabetes-induced in the animal model. |
| Databáze: | OpenAIRE |
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