Effect of a coat color locus on kidney lysosomal glycosidases in the house mouse
| Autor: | Lundin Lg, Håkansson Em |
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| Rok vydání: | 1977 |
| Předmět: |
Male
Heterozygote Locus (genetics) Biology Kidney Biochemistry Mice Genetics medicine Animals Hair Color Molecular Biology Gene Ecology Evolution Behavior and Systematics Glucuronidase chemistry.chemical_classification Galactosidases Homozygote Heterozygote advantage General Medicine Molecular biology Mice Inbred C57BL Hexosaminidases medicine.anatomical_structure Enzyme Genes chemistry Mice Inbred DBA Dihydrotestosterone Female Lysosomes medicine.drug |
| Zdroj: | Biochemical Genetics. 15:75-85 |
| ISSN: | 1573-4927 0006-2928 |
| DOI: | 10.1007/bf00484549 |
| Popis: | Activities of three lysosomal glycosidases, beta-galactosidase, beta-glucuronidase, and N-acetyl-beta-hexosaminidase, have been shown to differ in bf/bf and bf/+ mice. Thus bf/bf mice usually have much higher activities of these enzymes in their kidney cells than bf/+ animals. There seem, however, to be some exceptions to this general pattern, especially for galactosidase of females from the C57BL/6J strain. A likely interpretation of the difference is that the bf locus has pleiotropic effects. An alternative explanation, less likely, is that a gene closely linked to bf is involved. There is also a differential response to dihydrotestosterone in different groups of mice reflected in activity changes of the three enzymes. |
| Databáze: | OpenAIRE |
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