Multiple Stressors and the Response of Vascular Endothelial Cells: The Effect of Aging and Diabetes
| Autor: | Katie McLellan, Gurinder Bains, Scott W. Lee, Jerrold S. Petrofsky, Grenith J. Zimmerman, Michelle Prowse |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Aging medicine.medical_specialty Hot Temperature Endocrinology Diabetes and Metabolism Young Adult Endocrinology Reference Values Internal medicine Diabetes mellitus Diabetes Mellitus medicine Humans Laser doppler flow Increased blood flow Aged Skin business.industry Temperature Mean age Blood flow Middle Aged medicine.disease Surgery Medical Laboratory Technology Cardiology Endothelium Vascular Skin Temperature business Blood Flow Velocity Foot (unit) |
| Zdroj: | Diabetes Technology & Therapeutics. 11:73-79 |
| ISSN: | 1557-8593 1520-9156 |
| DOI: | 10.1089/dia.2008.0026 |
| Popis: | The present study examined the effects of local heat, global heat, and the interaction between these two endothelial stressors on the blood flow of the skin of the foot in people who are older and who have diabetes.Subjects who were older (mean age 64.2 +/- 5.9 years) and were younger (mean age 25.7 +/- 2.9 years) and subjects who had diabetes (mean age 62 +/- 5.9 years, mean duration 13.2 +/- 9.1 years) participated. Subjects were exposed to three global temperatures (16 degrees C, 24 degrees C, and 32 degrees C), and the blood flow response was recorded on the foot with a laser Doppler flow meter for 30 s following applications of local heat (30 degrees C, 33.5 degrees C, and 37 degrees C) using a Peltier junction to clamp the skin for 2 min.All three groups significantly increased blood flow from the 16-24 degrees C environments for the 37 degrees C application of local heat (P(Younger) = 0.02, P(Older) = 0.02, P(Diabetes) = 0.01). Those with diabetes and those who were older only increased blood flow 5% and 6% from the 24-32 degrees C environment, which was not statistically significant (P(Older) = 0.12, P(Diabetes) = 0.14).There appears to be considerable blood flow reserve in younger subjects to tolerate heat stress. In contrast, older subjects and those with diabetes reach a critical level after which additional heat does not cause in increase in blood flow. |
| Databáze: | OpenAIRE |
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