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Background: BReast CAncer gene (BRCA)1 and BRCA2 (also known as BRCA) mutation carriers are now frequently provided genetic counselling. A precise estimation of the prevalence of BRCA gene mutations is essential for the counsellor to provide an appropriate risk prediction. However, the data in Vietnam is ambiguous and unreliable risk factors from individual studies. Hence, the objective of this systematic review with meta-analysis protocol is to provide a method used to synthesize evidence pertaining to the proportion of BRCA mutations among Vietnamese women and their risk factors for cancers.Methods: Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P), a set of criteria for conducting systematic reviews, was followed in developing and reporting this protocol. From the databases' inception till June 2023, a comprehensive search will be undertaken in electronic PubMed and Scopus databases. In two stages, title/abstract screening and full-text screening, two independent authors will assess all retrieved articles for inclusion. This review includes papers providing the relevant results reflecting the prevalence of BRCA gene mutations in Vietnamese women who are at least 18 years old with or without cancer. Predefined selection criteria will be used to establish each publication's eligibility. Using the Newcastle-Ottawa Scale and Cochrane Risk of Bias tools, the quality of included studies will be assessed, and overall evidence quality will be appraised using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Initially, all pertinent data from the included articles will be entered into an online MS Excel spreadsheet for meta-analysis, which will thenbe imported into Rstudio. Meta-analyses using random effects will be used to obtain the pooled percentages. The chi-squared test and I2 parameter will be used to evaluate heterogeneity. Publication bias will be investigated visually using funnel plots for asymmetry and Egger's statistical tests.Conclusions:Based on the prevalence of BRCA muations and its comprehensive and specific risk factors for Vietnamese women, we hope our findings will be able to provide a reference for a future strategy to build an effective treatment plan and manage the risk of subsequent cancer development.Registration: PROSPERO (CRD42022340152; 30 June 2022). |
