Modulation of premotor cortex response to sequence motor learning during escitalopram intake
| Autor: | Harald E. Möller, Bernhard Sehm, Gergana Zheleva, Ralf Regenthal, Nathalie Beinhölzl, Julia Sacher, Arno Villringer, Maria Blöchl, Christopher J. Steele, Vadim V. Nikulin, André Pampel, Fabian A. Piecha, Eoin Molloy, Ulrike Scharrer, Karsten Mueller |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Functional magnetic resonance imaging Biology Citalopram Premotor cortex 03 medical and health sciences Young Adult 0302 clinical medicine sequential motor learning Double-Blind Method selective serotonin reuptake inhibitors Neuroplasticity Modulation (music) mental disorders medicine Escitalopram Humans Learning 030304 developmental biology Sequence (medicine) 0303 health sciences Neuronal Plasticity medicine.diagnostic_test Motor Cortex Original Articles Serotonin reuptake medicine.anatomical_structure Neurology post-stroke motor dysfunction Female Neurology (clinical) Cardiology and Cardiovascular Medicine Motor learning Neuroscience 030217 neurology & neurosurgery Psychomotor Performance medicine.drug neural plasticity |
| Zdroj: | Journal of Cerebral Blood Flow & Metabolism Journal of Cerebral Blood Flow and Metabolism |
| ISSN: | 1559-7016 |
| Popis: | The contribution of selective serotonin reuptake inhibitors to motor learning by inducing motor cortical plasticity remains controversial given diverse findings from positive preclinical data to negative findings in recent clinical trials. To empirically address this translational disparity, we use functional magnetic resonance imaging in a double-blind, randomized controlled study to assess whether 20 mg escitalopram improves sequence-specific motor performance and modulates cortical motor response in 64 healthy female participants. We found decreased left premotor cortex responses during sequence-specific learning performance comparing single dose and steady escitalopram state. Escitalopram plasma levels negatively correlated with the premotor cortex response. We did not find evidence in support of improved motor performance after a week of escitalopram intake. These findings do not support the conclusion that one week escitalopram intake increases motor performance but could reflect early adaptive plasticity with improved neural processing underlying similar task performance when steady peripheral escitalopram levels are reached. |
| Databáze: | OpenAIRE |
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