Assessment: Botulinum neurotoxin for the treatment of spasticity (an evidence-based review): [RETIRED]

Autor:	D M, Simpson, J-M, Gracies, H K, Graham, J M, Miyasaki, M, Naumann, B, Russman, L L, Simpson, Y, So
Rok vydání:	2008
Předmět:	Adult Clinical Trials as Topic Botulinum Toxins Evidence-Based Medicine Treatment Outcome Dose-Response Relationship Drug Muscle Spasticity Age Factors Humans Neurology (clinical) Neuromuscular Blocking Agents Child Muscle Skeletal
Zdroj:	Neurology. 70:1691-1698
ISSN:	1526-632X 0028-3878
DOI:	10.1212/01.wnl.0000311391.00944.c4
Popis:	Objective: To perform an evidence-based review of the safety and efficacy of botulinum neurotoxin (BoNT) in the treatment of adult and childhood spasticity.Methods: A literature search was performed including MEDLINE and Current Contents for therapeutic articles relevant to BoNT and spasticity. Authors reviewed, abstracted, and classified articles based on American Academy of Neurology criteria (Class I–IV).Results: The highest quality literature available for the respective indications was as follows: adult spasticity (14 Class I studies); spastic equinus and adductor spasticity in pediatric cerebral palsy (six Class I studies).Recommendations: Botulinum neurotoxin should be offered as a treatment option for the treatment of spasticity in adults and children (Level A).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07976e0aec61894d8e3e46e1adae9624 https://doi.org/10.1212/01.wnl.0000311391.00944.c4 Zobrazit plný text záznamu