Impact of stent overlap on long-term clinical outcomes in patients treated with newer-generation drug-eluting stents
| Autor: | Giulio G. Stefanini, Peter Wenaweser, Dik Heg, Peter Jüni, Aris Moschovitis, Thomas Pilgrim, Stephan Windecker, Thomas Zanchin, Bindu Kalesan, Crochan J. O'Sullivan, Masanori Taniwaki, Bernhard Meier, Ahmed A. Khattab, Lorenz Räber, Lutz Büllesfeld |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Drug
Adult Male medicine.medical_specialty media_common.quotation_subject medicine.medical_treatment Myocardial Infarction 610 Medicine & health Gastroenterology Time Coronary Restenosis 360 Social problems & social services Internal medicine medicine Clinical endpoint Humans In patient Myocardial infarction Everolimus Prospective Studies Prospective cohort study media_common Aged Aged 80 and over Sirolimus business.industry Stent Drug-Eluting Stents Middle Aged medicine.disease Surgery Clinical trial Treatment Outcome Female Cardiology and Cardiovascular Medicine business medicine.drug Follow-Up Studies |
| Zdroj: | O'Sullivan, Crochan John; Stefanini, Giulio; Räber, Lorenz; Heg, Dik; Taniwaki, Masanori; Kalesan, Bindu; Pilgrim, Thomas; Zanchin, Thomas; Moschovitis, Aris; Büllesfeld, Lutz; Khattab, Ahmed Aziz; Meier, Bernhard; Wenaweser, Peter Martin; Jüni, Peter; Windecker, Stephan (2014). Impact of stent overlap on long-term clinical outcomes in patients treated with newer-generation drug-eluting stents. EuroIntervention, 9(9), pp. 1076-1084. Europa Digital & Publishing 10.4244/EIJV9I9A182 |
| DOI: | 10.7892/boris.40848 |
| Popis: | Aims: Early-generation drug-eluting stent (DES) overlap (OL) is associated with impaired long-term clinical outcomes whereas the impact of OL with newer-generation DES is unknown. Our aim was to assess the impact of OL on long-term clinical outcomes among patients treated with newer-generation DES. Methods and results: We analysed the three-year clinical outcomes of 3,133 patients included in a prospective DES registry according to stent type (sirolimus-eluting stents [SES; N=1,532] versus everolimus-eluting stents [EES; N=1,601]), and the presence or absence of OL. The primary outcome was a composite of death, myocardial infarction (MI), and target vessel revascularisation (TVR). The primary endpoint was more common in patients with OL (25.1%) than in those with multiple DES without OL (20.8%, adj HR=1.46, 95% CI: 1.03-2.09) and patients with a single DES (18.8%, adj HR=1.74, 95% CI: 1.34-2.25, p |
| Databáze: | OpenAIRE |
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