Evaluation of antimicrobial prescriptions in dogs with suspected bacterial urinary tract disease
| Autor: | Jason W. Stull, Dennis Ballance, Philip J. Bergman, Talon McKee, Jinelle A. Webb, J. S. Weese |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Veterinary medicine Standard Article Cefpodoxime infectious diseases Dogs Marbofloxacin Anti-Infective Agents Interquartile range Clavulanic acid Internal medicine SF600-1100 medicine Antimicrobial stewardship Nephrology/Urology Animals Acute Cystitis Dog Diseases antimicrobial resistance Retrospective Studies General Veterinary Pyelonephritis business.industry Amoxicillin Antimicrobial Standard Articles United States Anti-Bacterial Agents antimicrobial stewardship Prescriptions SMALL ANIMAL business urinary tract infection medicine.drug |
| Zdroj: | Journal of Veterinary Internal Medicine, Vol 35, Iss 5, Pp 2277-2286 (2021) Journal of Veterinary Internal Medicine |
| ISSN: | 0891-6640 1939-1676 |
| Popis: | Background Antimicrobials are commonly used to treat urinary tract disease in dogs. Understanding antimicrobial use is a critical component of antimicrobial stewardship efforts. Hypothesis/objectives To evaluate antimicrobial prescriptions for dogs diagnosed with acute cystitis, recurrent cystitis, and pyelonephritis. Animals Dogs prescribed antimicrobials for urinary tract disease at veterinary practices in the United States and Canada. Materials and methods A retrospective review of antimicrobial prescriptions was performed. Results The main clinical concerns were sporadic bacterial cystitis (n = 6582), recurrent cystitis (n = 428), and pyelonephritis (n = 326). Amoxicillin/clavulanic acid (2702, 41%), cefpodoxime (1024, 16%), and amoxicillin (874, 13%) were most commonly prescribed for sporadic bacterial cystitis. The median prescribed duration was 12 days (range, 3-60 days; interquartile range [IQR], 4 days). Shorter durations were used in 2018 (median, 10 days; IQR, 4 days) compared to both 2016 and 2017 (both median, 14 days; IQR, 4 days; P ≤ .0002). Amoxicillin/clavulanic acid (146, 33%), marbofloxacin (95, 21%), and cefpodoxime (65, 14%) were most commonly used for recurrent cystitis; median duration of 14 days (range, 3-77 days; IQR, 10.5 days). Amoxicillin/clavulanic acid (86, 26%), marbofloxacin (56, 17%), and enrofloxacin (36, 11%) were most commonly prescribed for pyelonephritis; however, 93 (29%) dogs received drug combinations. The median duration of treatment was 14 days (range, 3-77 days; IQR, 11 days). Conclusions and clinical importance Decreases in duration and increased use of recommended first-line antimicrobials were encouraging. Common drug choices and durations should still be targets for antimicrobial stewardship programs that aim to optimize antimicrobial use, concurrently maximizing patient benefits while minimizing antimicrobial use and use of higher tier antimicrobials. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text