ANTAGONISM TO THE ACTIONS OF HYDRALLAZINE, RESERPINE, POTASSIUM CYANIDE, SODIUM AZIDE AND ANOXIA ON ARTERIAL SMOOTH MUSCLE
| Autor: | S. M. Kirpekar, J. J. Lewis |
|---|---|
| Rok vydání: | 1958 |
| Předmět: |
Azides
medicine.medical_specialty Reserpine Carbohydrates Potassium cyanide Pharmaceutical Science Carbohydrate metabolism Fats chemistry.chemical_compound Internal medicine medicine Hypoxia Potassium Cyanide Sodium Azide Receptor Pharmacology Cyanides Proteins Muscle Smooth Arteries Metabolism Hydralazine Lipid Metabolism Endocrinology chemistry Carbohydrate Metabolism Sodium azide Histamine Acetylcholine medicine.drug |
| Zdroj: | Journal of Pharmacy and Pharmacology. 10:307-314 |
| ISSN: | 2042-7158 0022-3573 |
| DOI: | 10.1111/j.2042-7158.1958.tb10307.x |
| Popis: | Many intermediates of carbohydrate, fat and protein metabolism give protection against the hydrallazine depression of acetylcholine, (-)-adrenaline, (-)-noradrenaline, histamine and 5-hydroxytryptamine-induced contractions of spirally cut strips of horse carotid arteries. Strips made anoxic behave in a manner similar to hydrallazine-treated strips. Inhibition of drug-induced contractions by potassium cyanide, iodoacetate and azide was of a different character from that caused by hydrallazine and anoxia. Few intermediates gave significant protection. Hydrallazine probably exerts its effect by a non-specific depression of metabolism rather than upon specific receptors. Reserpine depression of drug-induced contractions in artery strips was so persistent that experiments using intermediary metabolites could not be made. |
| Databáze: | OpenAIRE |
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