Scattering Angle Resolved Optical Coherence Tomography Detects Early Changes in 3xTg Alzheimer's Disease Mouse Model
| Autor: | Henry Grady Rylander, Vikram Baruah, Massoud Motamedi, Michael R. Gardner, Gracie Vargas, Thomas E. Milner |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Aging
Pathology Pilot Projects Neurodegenerative Inbred C57BL light scattering chemistry.chemical_compound Mice Medicine skin and connective tissue diseases Tomography medicine.diagnostic_test Neurodegeneration neurodegeneration Alzheimer's disease medicine.anatomical_structure Neurological Biomedical Imaging Tomography Optical Coherence Genetically modified mouse medicine.medical_specialty mouse model Biomedical Engineering Bioengineering Article Optical coherence tomography Opthalmology and Optometry Alzheimer Disease Acquired Cognitive Impairment Medical imaging Animals Humans Retina optical coherence tomography business.industry Scattering Neurosciences Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) Retinal medicine.disease eye diseases Brain Disorders 4.1 Discovery and preclinical testing of markers and technologies Mice Inbred C57BL Ophthalmology Alzheimers disease Cross-Sectional Studies chemistry Optical Coherence Angiography Dementia sense organs business |
| Zdroj: | Translational Vision Science & Technology Translational vision science & technology, vol 9, iss 5 |
| ISSN: | 2164-2591 |
| Popis: | Author(s): Gardner, Michael R; Baruah, Vikram; Vargas, Gracie; Motamedi, Massoud; Milner, Thomas E; Rylander, Henry G | Abstract: PurposeClinical intensity-based optical coherence tomographic retinal imaging is unable to resolve some of the earliest changes to Alzheimer's disease (AD) neurons. The aim of this pilot study was to demonstrate that scattering-angle-resolved optical coherence tomography (SAR-OCT), which is sensitive to changes in light scattering angle, is a candidate retinal imaging modality for early AD detection. SAR-OCT signal data may be sensitive to changes in intracellular constituent morphology that are not detectable with conventional OCT.MethodsIn this cross-sectional study, retinas of a triple transgenic mouse model of AD (3xTg-AD) were imaged alongside age-matched control mice (C57BL/6J) using SAR-OCT. A total of 32 mice (12 control, 20 3xTg-Ad) at four ages (10, 20, 30, and 45 weeks) were included in this cross-sectional study, and three retinal feature sets (scattering, thickness, and angiography) were examined between the disease and control groups.ResultsAD mice had significantly increased scattering diversity (lower SAR-OCT C parameter) at the earliest imaging time (10 weeks). Differences in the C parameter between AD and control mice were diminished at later times when both groups showed increased scattering diversity. AD mice have reduced retinal thickness compared to controls, particularly in central regions and superficial layers. No differences in vascular density or fractional blood volume between groups were detected.ConclusionsSAR-OCT is sensitive to scattering angle changes in a 3xTg-AD mouse model and could provide early-stage biomarkers for neurodegenerative diseases such as AD.Translational relevanceClinical OCT systems may be modified to record SAR-OCT images for non-invasive retinal diagnostic imaging of patients with neurodegenerative diseases such as AD. |
| Databáze: | OpenAIRE |
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