Pseudorabies virus glycoprotein gE triggers ERK1/2 phosphorylation and degradation of the pro-apoptotic protein Bim in epithelial cells
| Autor: | Bruno Verhasselt, Cliff Van Waesberghe, Hans Nauwynck, Maria Setas Lopes Pontes, Herman W. Favoreel |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
MAPK/ERK pathway Cancer Research Cell signaling MAP Kinase Signaling System Mitogen-Activated Protein Kinase 3 viruses Biology 03 medical and health sciences Viral Envelope Proteins Downregulation and upregulation Proto-Oncogene Proteins Virology Phosphorylation Mitogen-Activated Protein Kinase 1 Bcl-2-Like Protein 11 Kinase Membrane Proteins Epithelial Cells Herpesvirus 1 Suid Molecular biology 030104 developmental biology Infectious Diseases Apoptosis Host-Pathogen Interactions Proteolysis Apoptotic signaling pathway Apoptosis Regulatory Proteins Protein Processing Post-Translational |
| Zdroj: | Virus Research. 213:214-218 |
| ISSN: | 0168-1702 |
| DOI: | 10.1016/j.virusres.2015.12.008 |
| Popis: | ERK1/2 (Extracellular signal Regulated Kinase 1/2) signaling is a key cellular signaling axis controlling many cellular events, including cell survival. Activation of ERK 1/2 may trigger an anti-apoptotic response, and different viruses have been shown to benefit from this process. We have described recently that the viral glycoprotein gE mediates pseudorabies virus (PRV)-induced activation of ERK 1/2 in T lymphocytes. In the present study, we report that PRV gE-mediated ERK 1/2 phosphorylation also occurs in epithelial cells and that in these cells, gE-mediated ERK 1/2 signaling is associated with degradation of the pro-apoptotic protein Bim. Our results for the first time link the viral glycoprotein gE, an important alphaherpesvirus virulence factor, with the apoptotic signaling pathway. |
| Databáze: | OpenAIRE |
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