The regulation of cell size and branch complexity in the terminal cells of the Drosophila tracheal system
| Autor: | Alondra B Schweizer Burguete, Deanne Francis, Jeffrey B. Rosa, Amin S. Ghabrial |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Cell
Morphogenesis Context (language use) Protein Serine-Threonine Kinases Article 03 medical and health sciences 0302 clinical medicine medicine Animals Drosophila Proteins Molecular Biology Gene Drosophila Cell Size 030304 developmental biology 0303 health sciences biology Intracellular Signaling Peptides and Proteins Receptor Protein-Tyrosine Kinases Cell Biology biology.organism_classification Cell biology Trachea Drosophila melanogaster medicine.anatomical_structure Terminal (electronics) Larva Mutation 030217 neurology & neurosurgery Function (biology) Intracellular Developmental Biology |
| Zdroj: | Dev Biol |
| ISSN: | 0012-1606 |
| DOI: | 10.1016/j.ydbio.2019.02.001 |
| Popis: | The terminal cells of the larval Drosophila tracheal system extend dozens of branched cellular processes, most of which become hollow intracellular tubes that support gas exchange with internal tissues. Previously, we undertook a forward genetic mosaic screen to uncover the pathways regulating terminal cell size, morphogenesis, and the generation and maintenance of new intracellular tubes. Our initial work identified several mutations affecting terminal cell size and branch number, and suggested that branch complexity and cell size are typically coupled but could be genetically separated. To deepen our understanding of these processes, we have further characterized and determined the molecular identities of mutations in the genes sprout, denuded and asthmatic, that had been implicated in our initial screen. Here we reveal the molecular identity of these genes and describe their function in the context of the TOR and Hippo pathways, which are widely appreciated to be key regulators of cell and organ size. |
| Databáze: | OpenAIRE |
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