Tetrahydrobenzothiophene inhibitors of hepatitis C virus NS5B polymerase

Autor:	Diane Cebzanov, C. Faust, D. Ortlip, Lessen Thomas A, L. Leister, Thomas R. Bailey, Dorothy C. Young, Christopher J. Burns, Srinivas K. Chunduru, Eugene C. Amparo, Theodore J. Nitz, M.G. LaPorte
Rok vydání:	2005
Předmět:	Hepacivirus Hepatitis C virus Chemistry Pharmaceutical Clinical Biochemistry Drug Evaluation Preclinical Pharmaceutical Science Thiophenes Viral Nonstructural Proteins medicine.disease_cause Biochemistry Virus Flaviviridae chemistry.chemical_compound Structure-Activity Relationship Drug Discovery medicine Humans Enzyme Inhibitors Molecular Biology NS5B chemistry.chemical_classification Sulfonamides biology Chemistry Organic Chemistry virus diseases biology.organism_classification Nucleotidyltransferase RNA-Dependent RNA Polymerase Virology digestive system diseases Protein Structure Tertiary Enzyme Models Chemical Enzyme inhibitor Drug Design biology.protein Molecular Medicine Caco-2 Cells
Zdroj:	Bioorganicmedicinal chemistry letters. 16(1)
ISSN:	0960-894X
Popis:	A novel series of selective HCV NS5B RNA dependent RNA polymerase inhibitors has been disclosed. These compounds contain an appropriately substituted tetrahydrobenzothiophene scaffold. This communication will detail the SAR and activities of this series.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0790457da65da0dd2bbe76c1098483c9 https://pubmed.ncbi.nlm.nih.gov/16260131 Zobrazit plný text záznamu Full Text from ScienceDirect