Mouse models of adrenocortical tumors
| Autor: | Antonio M. Lerario, Kaitlin J. Basham, Gary D. Hammer, Holly A. Hung |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Biology medicine.disease_cause Biochemistry Article 03 medical and health sciences Mice 0302 clinical medicine Endocrinology Insulin-Like Growth Factor II medicine Adrenocortical carcinoma Animals Humans Molecular Biology Pathological Wnt Signaling Pathway Adrenal cortex Wnt signaling pathway Adrenal Cortex Neoplasm medicine.disease Adrenal Cortex Neoplasms Disease Models Animal 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Genetically Engineered Mouse Immunology Cancer research Tumor Suppressor Protein p53 Carcinogenesis Homeostasis |
| Zdroj: | Molecular and cellular endocrinology. 421 |
| ISSN: | 1872-8057 |
| Popis: | The molecular basis of the organogenesis, homeostasis, and tumorigenesis of the adrenal cortex has been the subject of intense study for many decades. Specifically, characterization of tumor predisposition syndromes with adrenocortical manifestations and molecular profiling of sporadic adrenocortical tumors have led to the discovery of key molecular pathways that promote pathological adrenal growth. However, given the observational nature of such studies, several important questions regarding the molecular pathogenesis of adrenocortical tumors have remained. This review will summarize naturally occurring and genetically engineered mouse models that have provided novel tools to explore the molecular and cellular underpinnings of adrenocortical tumors. New paradigms of cancer initiation, maintenance, and progression that have emerged from this work will be discussed. |
| Databáze: | OpenAIRE |
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