A Broad Role for the Zinc Finger Protein ZNF202 in Human Lipid Metabolism
| Autor: | Benjamin R. Bowen, Patricia Ormonde-Hanson, Mark H. Skolnick, Susanne Wagner, Dennis G. Ballinger, Mike Chen, Robert Kehrer, Michael Beluch, Christian Honer, Mark A. Hess, Michael Frodsham, Christoph Schumacher, Jennifer Malandro, Heping Hu |
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| Rok vydání: | 2000 |
| Předmět: |
Databases
Factual Genetic Linkage Hyperlipidemias ZNF202 Biochemistry Cell Line Gene product chemistry.chemical_compound Utah Humans Molecular Biology Zinc finger Regulation of gene expression Lipoprotein lipase Binding Sites biology Chromosomes Human Pair 11 Chromosome Mapping Zinc Fingers Lipid metabolism Cell Biology Lipid Metabolism DNA-Binding Proteins Repressor Proteins Alternative Splicing Apolipoproteins Gene Expression Regulation chemistry Chromosomal region Cholesteryl ester biology.protein lipids (amino acids peptides and proteins) Carrier Proteins Sequence Alignment Transcription Factors |
| Zdroj: | Journal of Biological Chemistry. 275:15685-15690 |
| ISSN: | 0021-9258 |
| DOI: | 10.1074/jbc.m910152199 |
| Popis: | The ZNF202 gene resides in a chromosomal region linked genetically to low high density lipoprotein cholesterol in Utah families. Here we show that the ZNF202 gene product is a transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), and several genes involved in processes related to energy metabolism and vascular disease. Based on the linkage and apparent transcriptional function of ZNF202, we propose that ZNF202 is a candidate susceptibility gene for human dyslipidemia. |
| Databáze: | OpenAIRE |
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