Electromyographic Findings in Nucleus Pulposus-Induced Radiculopathy in the Rat
| Autor: | Na-Hye Myong, Seong Jae Lee, Tai Ryoon Han, Jung Keun Hyun, Jae Yong Jeon |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Pathology medicine.medical_specialty Nerve root Electromyography Immunoenzyme Techniques Rats Sprague-Dawley Central nervous system disease chemistry.chemical_compound Ganglia Spinal Animals Medicine Orthopedics and Sports Medicine Fluorescent Antibody Technique Indirect Intervertebral Disc Muscle Skeletal Radiculopathy Paresis medicine.diagnostic_test business.industry Nitrotyrosine Anatomy musculoskeletal system medicine.disease Pathophysiology Rats Disease Models Animal Electrophysiology medicine.anatomical_structure chemistry Hyperalgesia Tyrosine Neurology (clinical) medicine.symptom Spinal Nerve Roots business Nucleus |
| Zdroj: | Spine. 31:2053-2058 |
| ISSN: | 0362-2436 |
| DOI: | 10.1097/01.brs.0000231741.66134.8e |
| Popis: | Study Design. This study was conducted to investigate the electromyographic changes and their pathophysiologic background in the animal model of nucleus pulposus-induced radiculopathy. Objectives. To observe the abnormal spontaneous activities in the electromyography (EMG) of rats with nucleus pulposus-induced radiculopathy and assess the role of nitric oxide in their development. Summary of Background Data. It has been shown that application of nucleus pulposus to nerve roots induces changes consistent with radiculopathy. However, to our knowledge, electromyographic findings and their background have never been studied in this model of radiculopathy. Methods. Autologous nucleus pulposus was harvested from the tails of Sprague-Dawley rats, and applied to L4 and L5 nerve roots. The rats were tested for mechanical allodynia, motor paresis, and needle EMG, before and after surgery. Specimens of nerve roots were stained histochemically for nitrotyrosine. Results. The rats had mechanical allodynia after surgery, but motor paresis was absent. EMG showed abnormal spontaneous activities after surgery, but only temporarily. Immunoreactivity for nitrotyrosine was detected in the cell bodies and axons of nerve roots. Conclusions. The data indicate that abnormal spontaneous activities can be observed in electromyographic examination of nucleus pulposus-induced radiculopathy. The development of these activities is considered related to nitric oxide-mediated protein nitration and resultant axonal dysfunction. |
| Databáze: | OpenAIRE |
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