The vSNAREs VAMP2 and VAMP4 control recycling and intracellular sorting of post-synaptic receptors in neuronal dendrites
| Autor: | Compans, Benjamin, Camus, Come, Kallergi, Emmanouela, Sposini, Silvia, Martineau, Magalie, Butler, Corey, Kechkar, Adel, Klaassen, Remco, Retailleau, Natacha, Sejnowski, Terrence, Smit, August, Sibarita, Jean-Baptiste, Bartol, Thomas, Perrais, David, Nikoletopoulou, Vassiliki, Choquet, Daniel, Hosy, Eric |
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| Přispěvatelé: | Interdisciplinary Institute for Neuroscience [Bordeaux] (IINS), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Bordeaux Imaging Center (BIC), Université de Bordeaux (UB)-Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHOQUET, Daniel, Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut François Magendie-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Vesicle-Associated Membrane Protein 2 [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology AMPA receptor Endosomes Neurotransmission Synaptic Transmission General Biochemistry Genetics and Molecular Biology Exocytosis R-SNARE Proteins Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Postsynaptic potential LTP induction Animals ComputingMilieux_MISCELLANEOUS 030304 developmental biology Neurons 0303 health sciences Neuronal Plasticity VAMP2 Chemistry [SDV.BA]Life Sciences [q-bio]/Animal biology musculoskeletal neural and ocular physiology [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Excitatory Postsynaptic Potentials Long-term potentiation Dendrites Cell biology nervous system Synaptic plasticity Synapses Female 030217 neurology & neurosurgery |
| Zdroj: | Cell Reports Cell Reports, 2021, 36 (10), pp.109678. ⟨10.1016/j.celrep.2021.109678⟩ Cell Reports, Elsevier Inc, 2021, 36 (10), pp.109678. ⟨10.1016/j.celrep.2021.109678⟩ |
| ISSN: | 2211-1247 |
| Popis: | International audience; Abstract Long-term depression (LTD) of synaptic strength can take multiple forms and contribute to circuit remodeling, memory encoding or erasure. The generic term LTD encompasses various induction pathways, including activation of NMDA, mGlu or P2X receptors. However, the associated specific molecular mechanisms and effects on synaptic physiology are still unclear. We here compare how NMDAR- or P2XR-dependent LTD affect synaptic nanoscale organization and function in rodents. While both LTDs are associated with a loss and reorganization of synaptic AMPARs, only NMDAR-dependent LTD induction triggers a profound reorganization of PSD-95. This modification, which requires the autophagy machinery to remove the T19-phosphorylated form of PSD-95 from synapses, leads to an increase in AMPAR surface mobility. We demonstrate that these post-synaptic changes that occur specifically during NMDAR-dependent LTD result in an increased short-term plasticity improving neuronal responsiveness of depressed synapses. Our results establish that P2XR- and NMDAR-mediated LTD are associated to functionally distinct forms of LTD. |
| Databáze: | OpenAIRE |
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