The decreased mean platelet volume is associated with poor prognosis in patients with oropharyngeal cancer treated with radiotherapy

Autor: Gabriele Jakse, Daniela Delago, Tanja Langsenlehner, Richard Partl, Sabine Reinisch, Wilfried Renner, Katarzyna Lukasiak, Heidi Stranzl-Lawatsch, Olivia Knittelfelder
Jazyk: angličtina
Rok vydání: 2020
Předmět:
lcsh:Medical physics. Medical radiology. Nuclear medicine
Adult
Male
medicine.medical_specialty
Multivariate analysis
medicine.medical_treatment
lcsh:R895-920
Mean platelet volume
Gastroenterology
lcsh:RC254-282
03 medical and health sciences
0302 clinical medicine
Decreased mean platelet volume
Internal medicine
Medicine
Humans
Radiology
Nuclear Medicine and imaging
030304 developmental biology
Outcome
Aged
0303 health sciences
Univariate analysis
Oropharyngeal cancer
Prognostic factor
business.industry
Proportional hazards model
Squamous Cell Carcinoma of Head and Neck
Research
Cancer
Biomarker
Middle Aged
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Prognosis
Radiation therapy
Oropharyngeal Neoplasms
Oncology
030220 oncology & carcinogenesis
Biomarker (medicine)
Female
business
Zdroj: Radiation Oncology (London, England)
Radiation Oncology, Vol 15, Iss 1, Pp 1-12 (2020)
ISSN: 1748-717X
Popis: Background There is considerable evidence that platelets contribute to cancer growth and metastatic dissemination. In recent studies, altered mean platelet volume (MPV) has been associated with prognosis in different types of cancer. However, the prognostic role of the MPV in head and neck squamous cell cancer (HNSCC) is currently discussed controversially. The present study was performed to analyze and further elucidate the prognostic significance of the MPV in HNSCC. Methods A total of 319 oropharyngeal squamous cell cancer (OPSCC) patients treated with radiotherapy at a tertiary academic center were enrolled in the present study. Kaplan–Meier method as well as uni- and multivariate Cox proportional hazards were used to evaluate the impact of MPV on cancer-specific survival (CSS), locoregional control (LC) and recurrence-free survival (RFS). Results The median MPV was 10.30 fL (mean 10.26 ± 1.17fL). Univariate analyses showed a significant association of the MPV with CSS (HR 0.85, 95% CI 0.74–0.98, p = 0.025), LC (HR 0.86, 95% CI 0.74–0.99, p = 0.034) and RFS (HR 0.87, 95% CI 0.76–0.996; p = 0.043). In multivariate analysis, the MPV remained an independent prognostic factor for CSS (HR 0.77, 95% CI 0.63–0.93, p = 0.008), LC (HR 0.80, 95% CI 0.65–0.98, p = 0.030), and RFS (HR 0.83, 95% CI 0.685–0.999, p = 0.049). Conclusions Our findings indicate that the MPV is a prognostic marker in OPSCC patients and may contribute to future individual risk assessment.
Databáze: OpenAIRE
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