A quantitative difference in the activity of blood group A-specific N-acetylgalactosaminyltransferase in serum from A1 and A2 human subjects
| Autor: | Marie C. Crookston, M. Alex Micheals, Harry Schachter, C. A. Tilley, J. H. Crookston |
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| Rok vydání: | 1971 |
| Předmět: |
medicine.medical_specialty
Chromatography Paper Swine Uracil Nucleotides Submandibular Gland Biophysics Oligosaccharides Galactosamine Immunogenetics Biochemistry Group A ABO Blood-Group System Chimera (genetics) chemistry.chemical_compound Pregnancy Transferases Internal medicine ABO blood group system Glycosyltransferase medicine Animals Humans Molecular Biology Carbon Isotopes biology Mosaicism business.industry Mucins Cell Biology Haematopoiesis Endocrinology chemistry Immunology biology.protein Female business Uracil nucleotide |
| Zdroj: | Biochemical and Biophysical Research Communications. 45:1011-1018 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/0006-291x(71)90438-4 |
| Popis: | A soluble glycosyltransferase which can trasfer N-acetylgalactosamine from UDP-N-acetylgalactosamine to exogenous acceptors is present in the serum of human subjects with the blood group A gene. The enzyme is in the serum of secretors and non-secretors of group A and AB but is not in the serum of group 0 or B subjects. The activity of serum from A 1 subjects is 5 to 10 times higher than that from A 2 subjects. Activity was lower in two group A 1 pregnant women. There was low activity in the serum of a hematopoietic chimera whose A 1 gene is restricted to her “grafted” blood cells. |
| Databáze: | OpenAIRE |
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