Renal norepinephrine spillover during infusion of nonesterified fatty acids
| Autor: | Mark A. Supiano, Chardpra Orn Ngarmukos, David M. Williams, Roger J. Grekin |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Sympathetic nervous system medicine.medical_specialty Fat Emulsions Intravenous Hypertension Renal Sympathetic Nervous System Fatty Acids Nonesterified Kidney Tritium Norepinephrine (medication) Norepinephrine Infusion Procedure Internal medicine Renin Internal Medicine medicine Humans Obesity chemistry.chemical_classification business.industry Heparin Fatty acid Anticoagulants Venous Plasma Venous blood medicine.anatomical_structure Endocrinology chemistry Catecholamine Female business medicine.drug |
| Zdroj: | American journal of hypertension. 18(3) |
| ISSN: | 0895-7061 |
| Popis: | Background Sympathetic activity and renal norepinephrine spillover are increased in obese individuals. We have reported that infusion of nonesterified fatty acids increases blood pressure in animals through stimulation of the sympathetic nervous system. Methods In this study, we assessed the effect of increasing circulating nonesterified fatty acids on systemic and renal norepinephrine kinetics in healthy adults by infusing fat emulsion and heparin for 4 h. 3H-norepinephrine was infused for 60 min before and again during the last hour of the fatty acid infusion to assess norepinephrine kinetics. Renal venous blood samples were obtained to calculate renal norepinephrine spillover. Results Nonesterified fatty acid levels increased threefold during the first hour and remained elevated throughout the study. Arterial and renal venous plasma norepinephrine levels fell by 15% and 20%, respectively, during the infusion (P < .05 for both). Kinetic analysis indicated that systemic release of norepinephrine into an extravascular compartment decreased from 11.6 ± 1.1 to 10.0 ± 1.3 nmol/min/m2 (P = .067) and renal venous norepinephrine spillover decreased from 454 ± 54 pmol/min (P = .055). Conclusions These results indicate that nonesterified fatty acids do not have a direct stimulating effect on whole-body or renal sympathetic activity. It is possible that increased plasma levels of fatty acids serve as a signal to decrease sympathetic tone during the fasting state. |
| Databáze: | OpenAIRE |
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