Hypoxia Inducible Factor (HIF) Hydroxylases as Regulators of Intestinal Epithelial Barrier Function
| Autor: | Mario C. Manresa, Cormac T. Taylor |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Epithelial Barrier Cell NF-κB nuclear factor-κB Review Disease Biology Inflammatory bowel disease Hypoxia-Inducible Factor (HIF) Hydroxylases FIH factor inhibiting hypoxia-inducible factor 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine ZO zonula occludens CD Crohn’s disease medicine DSS dextran sodium sulfate lcsh:RC799-869 Hypoxia TNF-α tumor necrosis factor α Barrier function Lung DMOG dimethyloxalylglycine IBD inflammatory bowel disease Hepatology Inflammatory Bowel Disease Gastroenterology NF-κB Hypoxia (medical) medicine.disease IL interleukin 3. Good health Cell biology HIF hypoxia-inducible factor UC ulcerative colitis TJ tight junction 030104 developmental biology medicine.anatomical_structure chemistry Hypoxia-inducible factors TFF trefoil factor 030220 oncology & carcinogenesis Immunology PHD hypoxia-inducible factor–prolyl hydroxylases lcsh:Diseases of the digestive system. Gastroenterology medicine.symptom TLR Toll-like receptor |
| Zdroj: | Cellular and Molecular Gastroenterology and Hepatology, Vol 3, Iss 3, Pp 303-315 (2017) Cellular and Molecular Gastroenterology and Hepatology |
| ISSN: | 2352-345X |
| DOI: | 10.1016/j.jcmgh.2017.02.004 |
| Popis: | Human health is dependent on the ability of the body to extract nutrients, fluids, and oxygen from the external environment while at the same time maintaining a state of internal sterility. Therefore, the cell layers that cover the surface areas of the body such as the lung, skin, and gastrointestinal mucosa provide vital semipermeable barriers that allow the transport of essential nutrients, fluid, and waste products, while at the same time keeping the internal compartments free of microbial organisms. These epithelial surfaces are highly specialized and differ in their anatomic structure depending on their location to provide appropriate and effective site-specific barrier function. Given this important role, it is not surprising that significant disease often is associated with alterations in epithelial barrier function. Examples of such diseases include inflammatory bowel disease, chronic obstructive pulmonary disease, and atopic dermatitis. These chronic inflammatory disorders often are characterized by diminished tissue oxygen levels (hypoxia). Hypoxia triggers an adaptive transcriptional response governed by hypoxia-inducible factors (HIFs), which are repressed by a family of oxygen-sensing HIF hydroxylases. Here, we review recent evidence suggesting that pharmacologic hydroxylase inhibition may be of therapeutic benefit in inflammatory bowel disease through the promotion of intestinal epithelial barrier function through both HIF-dependent and HIF-independent mechanisms. Keywords: Epithelial Barrier, Inflammatory Bowel Disease, Hypoxia, Hypoxia-Inducible Factor (HIF) Hydroxylases |
| Databáze: | OpenAIRE |
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