Interferon system deficiencies exacerbating severe pandemic virus infections

Autor: Stertz, Silke, Hale, Benjamin G
Přispěvatelé: University of Zurich, Hale, Benjamin G
Rok vydání: 2021
Předmět:
10028 Institute of Medical Virology
autoantibodies
Autoimmunity
Severity of Illness Index
2726 Microbiology (medical)
Loss of Function Mutation
Interferon
Pandemic
Pathogen
Disease Resistance
COVID
0303 health sciences
2404 Microbiology
interferon
3. Good health
Infectious Diseases
Virus Diseases
Host-Pathogen Interactions
Disease Progression
disease severity
Disease Susceptibility
Antibody
influenza
medicine.drug
Microbiology (medical)
Opinion
610 Medicine & health
Biology
Polymorphism
Single Nucleotide
Microbiology
Virus
03 medical and health sciences
Immunity
Virology
medicine
Animals
Humans
Genetic Predisposition to Disease
Alleles
030304 developmental biology
030306 microbiology
Autoantibody
COVID-19
2725 Infectious Diseases
Antibodies
Neutralizing
host genetics
Viral replication
Immunology
2406 Virology
biology.protein
pandemic virus
570 Life sciences
biology
Interferons
Zdroj: Trends in Microbiology
ISSN: 0966-842X
DOI: 10.1016/j.tim.2021.03.001
Popis: Pandemics are caused by novel pathogens to which pre-existing antibody immunity is lacking. Under these circumstances, the body must rely on innate interferon-mediated defenses to limit pathogen replication and allow development of critical humoral protection. Here, we highlight studies on disease susceptibility during H1N1 influenza and COVID-19 (SARS-CoV-2) pandemics. An emerging concept is that genetic and non-genetic deficiencies in interferon system components lead to uncontrolled virus replication and severe illness in a subset of people. Intriguingly, new findings suggest that individuals with autoantibodies neutralizing the antiviral function of interferon are at increased risk of severe COVID-19. We discuss key questions surrounding how such autoantibodies develop and function, as well as the general implications of diagnosing interferon deficiencies for personalized therapies.
Databáze: OpenAIRE
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