Ellagic acid attenuates liver toxicity induced by valproic acid in rats
| Autor: | Mohammed F. El-Yamany, Naglaa Assaf, Wesam H. Elesawy, Noha F. Abdelkader, Amany M. Gad, Hala M. Fawzy |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Drug Male media_common.quotation_subject Pharmacology medicine.disease_cause Nitric Oxide Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound Epilepsy Hydroxyproline 0302 clinical medicine Ellagic Acid medicine Animals Aspartate Aminotransferases media_common Valproic Acid lcsh:RM1-950 Alanine Transaminase Glutathione medicine.disease Alkaline Phosphatase Oxidative Stress 030104 developmental biology lcsh:Therapeutics. Pharmacology chemistry Liver Concomitant Molecular Medicine lipids (amino acids peptides and proteins) Chemical and Drug Induced Liver Injury 030217 neurology & neurosurgery Oxidative stress Ellagic acid medicine.drug Phytotherapy |
| Zdroj: | Journal of Pharmacological Sciences, Vol 143, Iss 1, Pp 23-29 (2020) |
| ISSN: | 1347-8613 |
| Popis: | Valproic acid is a commonly used drug for many psychiatric disorders, particularly for epilepsy. However, it has been reported that its use is associated with possible side effects including hepatotoxicity.The present study investigated the hepatoprotective effect of ellagic acid against valproic acid-induced hepatotoxicity in rats.Ellagic acid (60 mg/kg/day; p.o) was treated for one week, followed by concomitant injection of valproic acid (250 mg/kg/day; i.p.) for another 14 consecutive days to induce hepatocellular damage in adult Sprague–Dawley rats.Valproic acid showed a marked increase in serum enzyme activities, AST, ALT, ALP and GGT. In addition, it significantly increased MDA and NO along with a marked decline in reduced GSH content. At the same time, valproic acid administration resulted in marked elevation in hydroxyproline, TNF-α production and NF-kB expression. These results were confirmed by histopathological examination.Treatment with ellagic acid markedly attenuated valproic acid-induced hepatic injury in rats. Keywords: Valproic acid, Hepatotoxicity, Oxidative stress, Ellagic acid, Hepatocellular damage |
| Databáze: | OpenAIRE |
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