Lack of Alterations in Thyroid Hormones Following Exposure to Polybrominated Diphenyl Ether 47 during a Period of Rapid Brain Development in Mice

Autor:	Joan M. Hedge, Virginia C. Moser, Jillian R. Gee
Rok vydání:	2008
Předmět:	Male endocrine system medicine.medical_specialty Time Factors Ratón Health Toxicology and Mutagenesis Central nervous system Toxicology Cerebro Mice chemistry.chemical_compound Internal medicine Halogenated Diphenyl Ethers medicine Animals reproductive and urinary physiology Pharmacology Chemical Health and Safety Triiodothyronine Behavior Animal Chemistry Phenyl Ethers Body Weight Thyroid Diphenyl ether Public Health Environmental and Occupational Health Brain General Medicine Hydrocarbons Brominated Mice Inbred C57BL Thyroxine Endocrinology medicine.anatomical_structure Toxicity Hormone
Zdroj:	Drug and Chemical Toxicology. 31:245-254
ISSN:	1525-6014 0148-0545
DOI:	10.1080/01480540701873194
Popis:	Thyroid alterations have been shown to occur following exposure to polybrominated diphenyl ether (PBDE) mixtures, possibly indicating that disruptions in thyroid hormone levels may underlie behavior deficits observed in animals following postnatal PBDE exposure. This study determined whether acute postnatal exposure to PBDE-47 would alter thyroid hormones. Mice were dosed with PBDE-47 on postnatal day 10, and serum collected either 1, 5, or 10 days after the dose. No effect was observed on thyroxine and triiodothyronine levels at any age examined. This suggests that the neurological abnormalities reported in mice exposed to PBDE-47 are not due to acute changes in circulating thyroid hormones at these observed periods.
Databáze:	OpenAIRE
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