A CHILD WITH LARON SYNDROME ASSOCIATED WITH VASCULITIS
| Autor: | Ülkü Tiraş, Y Dallar Bilge, S Savas Erdeve, R Unsal Sac, Medine Ayşin Taşar |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Autoimmune disease Pediatrics medicine.medical_specialty medicine.diagnostic_test Endocrine and Autonomic Systems business.industry Endocrinology Diabetes and Metabolism medicine.medical_treatment Growth factor Physical examination Case Report medicine.disease 03 medical and health sciences Insulin-like growth factor 030104 developmental biology 0302 clinical medicine Endocrinology 030225 pediatrics medicine Laron syndrome Complication Vasculitis business Infectious agent |
| Popis: | Background and objectives Levels of insulin-like growth factor-I are characteristically low in Laron syndrome which is a factor that has important roles on vascular health and development. Congenital insulin-like growth factor-I deficiency was reported to be associated with some vascular disorders. However, vasculitis diseases and Laron Syndrome association has not been reported in English literature up to date. Patient We report the case of a two and a half years old Turkish girl, who was diagnosed as Laron syndrome when she was 12 months old. She presented with acute vasculitis lesions. Her physical examination and laboratory studies did not reveal a specific infectious agent or also an autoimmune disease was not detected. Her lesions disappeared during hospitalization without a complication. Conclusion Since insulin-like growth factor-I reduces endothelial cell oxidative stress and maintains the structural integrity of vessels, some common mechanisms might be responsible for the occurrence of vasculitis in this patient with Laron syndome. The role of insulin-like growth factor-I and recombinant human insulin-like growth factor-I treatment choice in vasculitis diseases is a matter of investigation. |
| Databáze: | OpenAIRE |
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