Unraveling the importance of molecules of natural origin in antifungal drug development through targeting ergosterol biosynthesis pathway
| Autor: | Mansoor Khoramizadeh, Fatemehsadat Jamzivar, Mehdi Razzaghi-Abyaneh, Mohammadhassan Gholami-Shabani, Masoomeh Shams-Ghahfarokhi, Niloufar Yousefi |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
Antifungal drugs Antifungal drug lcsh:QR1-502 Drug design Review Article Drug resistance Natural compounds Biology 01 natural sciences Microbiology lcsh:Microbiology Fungal infections chemistry.chemical_compound Immune system 0502 economics and business 0101 mathematics Antifungal drug discovery Ergosterol 010102 general mathematics 05 social sciences Sterol Ergosterol biosynthesis chemistry 050203 business & management |
| Zdroj: | Iranian Journal of Microbiology, Vol 11, Iss 6 (2020) Iranian Journal of Microbiology |
| ISSN: | 2008-4447 2008-3289 |
| Popis: | Over the past decades, the incidence of life-threatening fungal infections has increased dramatically in particular among patients with hampered immune function. Fungal infections cause around 1.5 million deaths annually, superior to malaria and tuberculosis. With respect to high toxicity, narrow spectrum of activity and drug resistance to current antifungals, there is an urgent need to discover novel leads from molecules of natural origin especially those derived from plants and microorgan- isms for antifungal drug discovery. Among antifungal drugs introduced into the clinic, those affecting ergosterol biosynthesis are still superior to other classes and the vital role of ergosterol in fungal growth and development. This review highlights current knowledge about available antifungal agents and further issues on antifungal drug discovery from compounds of nat- ural origin which affect ergosterol biosynthesis. Special attention is made to the fungal sterol C24-methyltransferase (SMT), a crucial enzyme in ergosterol biosynthesis pathway as a novel target for rational drug design. |
| Databáze: | OpenAIRE |
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