Prone position versus supine position in postoperative radiotherapy for breast cancer: A meta-analysis
| Autor: | Jianxiong Deng, Junming Lai, Yongbiao Luo, Hui Luo, Shuang Hu, Ruoyan Shen, Fangyan Zhong |
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| Rok vydání: | 2020 |
| Předmět: |
Organs at Risk
Supine position medicine.medical_treatment Breast Neoplasms Anterior Descending Coronary Artery Patient Positioning 03 medical and health sciences 0302 clinical medicine Breast cancer breast cancer Medicine Humans 030212 general & internal medicine Radiation Injuries Radiometry Lung Mastectomy radiotherapy deep inspiration breath hold supine position business.industry Heart Radiotherapy Dosage General Medicine medicine.disease Coronary Vessels Confidence interval Radiation therapy meta-analysis Prone position Strictly standardized mean difference 030220 oncology & carcinogenesis prone position Female Radiotherapy Adjuvant business Nuclear medicine Organ Sparing Treatments Systematic Review and Meta-Analysis Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | Background: This meta-analysis evaluates the difference of sparing organs at risk (OAR) in different position (Prone position and Supine position) with different breathing patterns (Free breathing, FB/Deep inspiration breath hold, DIBH) for breast cancer patients receiving postoperative radiotherapy and provides a useful reference for clinical practice. Method: The relevant controlled trials of prone position versus supine position in postoperative radiotherapy for breast cancer were retrieved from the sources of PubMed, Cochrane Library, Embase, Web of Science and ClinicalTrails.gov. The principal outcome of interest was OAR doses (heart dose, left anterior descending coronary artery dose and ipsilateral lung dose) and target coverage. We mainly compared the effects of P-FB (Prone position FB) and S-FB (Supine position FB) and discussed the effects of DIBH combined with different positions on OAR dose in postoperative radiotherapy. We calculated summary standardized mean difference (SMD) and 95% confidence intervals (CI). The meta-analysis was performed using RevMan 5.4 software. Results: The analysis included 751 patients from 19 observational studies. Compared with the S-FB, the P-FB can have lower heart dose, left anterior descending coronary artery (LADCA) dose, and ipsilateral lung dose (ILL) more effectively, and the difference was statistically significant (heart dose, SMD = − 0.51, 95% CI − 0.66 ∼ − 0.36, P |
| Databáze: | OpenAIRE |
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