Acute generalized exanthematous pustulosis in cystic echinococcosis: immunological characterization
| Autor: | F. Bassetti, Elena Ortona, C. Cannistraci, Mauro Picardo, I. L. La Parola, S. Siracusano, Baldassarre Santucci, Rachele Riganò |
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| Rok vydání: | 2003 |
| Předmět: |
Echinococcosis
Hepatic Pathology medicine.medical_specialty Urticaria medicine.medical_treatment Immunoblotting Helminthiasis Dermatology Immunoglobulin E Antigen parasitic diseases medicine Humans Skin Diseases Parasitic Echinococcus granulosus Aged Skin Diseases Vesiculobullous biology business.industry Exanthema medicine.disease biology.organism_classification Acute generalized exanthematous pustulosis Echinococcosis Cytokine Antigens Helminth Antibody Formation Immunology Leukocytes Mononuclear biology.protein Cytokines Female Antibody business |
| Zdroj: | British Journal of Dermatology. 148:1245-1249 |
| ISSN: | 1365-2133 0007-0963 |
| DOI: | 10.1046/j.1365-2133.2003.05346.x |
| Popis: | We report the first case, to the best of our knowledge, of a woman suffering from cystic echinococcosis of the liver, who consequently developed urticaria and acute generalized exanthematous pustolosis (AGEP). Serum immunoglobulin (Ig)E and IgG4 specific to Echinococcus granulosus antigens were detected by immunoblotting. Furthermore, the intracellular cytokine analysis revealed a prevalent T-helper 2 polarization. It can be reasoned that, while the presence of IgE specific to various E. granulosus allergens may be responsible for the chronic urticarial manifestations, the detection of IgG4 specific for E. granulosus antigens, forming immunocomplexes, may be related to the development of the AGEP. |
| Databáze: | OpenAIRE |
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