Use of bivalirudin, a direct thrombin inhibitor, and its reversal with modified ultrafiltration during heart transplantation in a patient with heparin-induced thrombocytopenia

Autor:	Anil De Silva, Michael J. Mann, Teresa DeMarco, Elaine E. Tseng, Greg Strattman, Nancy L. Achorn, Charles W. Hoopes, William F. Moskalik, Mark B. Ratcliffe
Rok vydání:	2005
Předmět:	Adult Cardiomyopathy Dilated Male Pulmonary and Respiratory Medicine medicine.medical_specialty medicine.medical_treatment Context (language use) Heparin-induced thrombocytopenia Internal medicine Hemofiltration Humans Medicine Bivalirudin Heart Failure Heart transplantation Transplantation Intraoperative Care Dose-Response Relationship Drug Heparin business.industry Thrombin Anticoagulants Hirudins medicine.disease Combined Modality Therapy Thrombocytopenia Peptide Fragments Recombinant Proteins Surgery Direct thrombin inhibitor Cardiology Heart Transplantation Cardiology and Cardiovascular Medicine business medicine.drug
Zdroj:	The Journal of Heart and Lung Transplantation. 24:222-225
ISSN:	1053-2498
DOI:	10.1016/j.healun.2003.11.401
Popis:	Heparin-induced thrombocytopenia (HIT) is an increasingly common clinical finding in patients presenting for cardiac transplantation. Bivalrudin, a reversible direct thrombin inhibitor, is a molecular anti-coagulant with short half-life and the potential for removal by intraoperative hemofiltration. Herein we describe the dosing and intraoperative management of bivalrudin anti-coagulation in a patient undergoing urgent cardiac transplantation in the context of recently diagnosed HIT.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::077fbb823168ddd67f127b3fe8104c0e https://doi.org/10.1016/j.healun.2003.11.401 Zobrazit plný text záznamu