Regulation of GATA gene expression during vertebrate development
| Autor: | John B.E. Burch |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
GATA5 Transcription Factor
Transgene GATA3 Transcription Factor Biology GATA6 Transcription Factor Gene expression Animals Enhancer Gene Genetics Regulation of gene expression GATA2 Fishes Gene Expression Regulation Developmental Heart Cell Biology GATA4 Transcription Factor Cell biology DNA-Binding Proteins GATA2 Transcription Factor Intestines Enhancer Elements Genetic Vertebrates embryonic structures Trans-Activators Erythroid-Specific DNA-Binding Factors GATA transcription factor Transcription Factors Developmental Biology |
| Zdroj: | Seminars in Cell & Developmental Biology. 16:71-81 |
| ISSN: | 1084-9521 |
| Popis: | GATA factors regulate critical events in hematopoietic lineages (GATA-1/2/3), the heart and gut (GATA-4/5/6) and various other tissues. Transgenic approaches have revealed that GATA genes are regulated in a modular fashion by sets of enhancers that govern distinct temporal and/or spatial facets of the overall expression patterns. Efforts are underway to resolve how these GATA gene enhancers are themselves regulated in order to elucidate the genetic and molecular hierarchies that govern GATA expression in particular developmental contexts. These enhancers also afford a raft of tools that can be used to selectively perturb and probe various developmental events in transgenic animals. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect