Relationship of Established Cardiovascular Risk Factors and Peripheral Biomarkers on Cognitive Function in Adults at Risk of Cognitive Deterioration
| Autor: | David Ames, Michelle Lai, Ralph N. Martins, Nicola T. Lautenschlager, Graham Hepworth, Patricia Desmond, Elizabeth V. Cyarto, Kathryn A. Ellis, Matthew J. Sharman, Kay L. Cox, Colin L. Masters |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Oncology medicine.medical_specialty Trail Making Test Population Executive Function 03 medical and health sciences Cognition 0302 clinical medicine Memory Risk Factors Internal medicine medicine Humans Cognitive Dysfunction Effects of sleep deprivation on cognitive performance education Aged Aged 80 and over Inflammation education.field_of_study Mini–Mental State Examination Framingham Risk Score medicine.diagnostic_test business.industry Microcirculation General Neuroscience Australia General Medicine Neuropsychological test Middle Aged Mental Status and Dementia Tests medicine.disease Psychiatry and Mental health Clinical Psychology Cross-Sectional Studies 030104 developmental biology Heart Disease Risk Factors Female Inflammation Mediators Geriatrics and Gerontology Alzheimer's disease business Biomarkers Psychomotor Performance 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's Disease. 74:163-171 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-190953 |
| Popis: | Background: There is a paucity of information on the role of microvascular and inflammatory biomarkers in cognitive dysfunction. Objective: This study sought to evaluate the relationships between established and a number of peripheral biomarkers on cognitive patterns in 108 older adults with memory complaints. Methods: Participants in the AIBL Active study aged 60 years and older with at least one vascular risk factor and memory complaints completed a neuropsychological test battery and provided cross-sectional health data. Linear regression models adjusted for covariates examined associations between cognitive performance and a panel of vascular risk factors (Framingham cardiovascular scores, hs-CRP, homocysteine, fasting glucose, LDL-cholesterol) and peripheral biomarkers (TNF-α, BDNF, VCAM-1, ICAM-1, PAI-1, CD40L). Results: Higher fasting glucose and homocysteine levels were independent factors associated with poorer performance in Trail Making Test (TMT) B (adjusted β= 0.40±0.10 and 0.43±0.09, respectively). Increasing homocysteine levels were weakly associated with poorer global cognition and delayed recall (adjusted β= 0.23±0.10 and -0.20±0.10 respectively). Increasing Framingham cardiovascular scores were related to poorer performance in TMT B (β = 0.42±0.19). There was early evidence of associations between increasing plasma TNF-α and poorer TMT B (adjusted β = 0.21±0.10) and between increasing BDNF and better global cognition (β= -0.20±0.09). Conclusion: This study provides evidence to support the associations between vascular risk factors (Framingham scores, fasting glucose, and homocysteine) and poorer cognitive functions. Additionally, we measured several peripheral biomarkers to further investigate their associations with cognition. The relationship between TNF-α, BDNF, and cognitive performance in various domains may offer new insights into potential mechanisms in vascular cognitive impairment. |
| Databáze: | OpenAIRE |
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