A gp120 HIV peptide with high similarity to HLA class II beta chains enhances PPD-specific and autoreactive T cell activation
| Autor: | B Camponeschi, Marina Viora, F Caprilli, V. Colizzi, M Evangelista, Orsola Pugliese, A. Chersi, P. Cordiali Fei, A M Di Massimo |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
T cell
T-Lymphocytes Immunology Antigen presentation Molecular Sequence Data Peptide Human leukocyte antigen Cross Reactions HIV Antibodies HIV Envelope Protein gp120 Major histocompatibility complex Lymphocyte Activation Tuberculin Autoantigens HIV Seropositivity medicine Immunology and Allergy Humans Amino Acid Sequence Peptide sequence HLA-DR Antigen chemistry.chemical_classification biology virus diseases HLA-DR Antigens medicine.anatomical_structure chemistry biology.protein Antibody Peptides Research Article |
| Zdroj: | Clinical and experimental immunology. 90(2) |
| ISSN: | 0009-9104 |
| Popis: | SUMMARY The recent report that anli-gp120 antibodies can be induced by allogeneic stimuli in experimental animals in the absence of HIV, has focused attention on the structural similarities between gp120 and MHC. Here we report that some HIV+ individuals develop antibodies which similarly react with the gp120 HIV sequence (aa 254–263) and with the HLA-DR β chains (aa 142–151). As these two peptides share a high level of similarity, we have investigated the role of this gp120 region on HLA class II mediated T cell recognition. The synthetic peptide corresponding to the gp120 HIV sequence aa 254–263 has been tested on T cell line (TCL) activation. Both the PPD-specific and the self-HLA reactive TCL proliferation increased in the presence of this peptide. Prepulsing experiments indicate that this enhancing effect carried out by HIV peptide is exerted at the level of antigen presentation. Moreover, the specificity of this interaction is supported by the fact that a MoAb specific for this HIV peptide blocked the autoreactive TCL proliferation, similarly to the inhibition carried out by anti-class II antibody. These data support the hypothesis that the functional homology between the HIV peptide and the HLA β chain described may be involved in the pathogenesis of AIDS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text