Leukocyte Hexokinase Activity in Aging and Alzheimer Disease
| Autor: | Piero Antuono, K. Nicholson, J. Ravanelli-Meyer, Alan S. Bloom |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Aging medicine.medical_specialty Clinical variables Cognitive Neuroscience Clinical marker Disease Biology Central nervous system disease chemistry.chemical_compound Degenerative disease Alzheimer Disease Hexokinase Internal medicine Leukocytes medicine Humans Family Aged Hexokinase activity Age Factors Middle Aged medicine.disease Psychiatry and Mental health Endocrinology chemistry Geriatrics and Gerontology Alzheimer's disease Energy Metabolism |
| Zdroj: | Dementia and Geriatric Cognitive Disorders. 6:200-204 |
| ISSN: | 1421-9824 1420-8008 |
| DOI: | 10.1159/000106947 |
| Popis: | We determined the effects of clinical variables on hexokinase (HK) activity in leukocytes from Alzheimer''s disease (AD) patients and controls. Age accounted for 51% of the variance in HK activity in the young and 23% in the old. Duration of illness in both familial and sporadic AD accounted for HK levels by 32 and 38%, respectively. Hexokinase activity increases with age and does not discriminate between familial and sporadic AD. |
| Databáze: | OpenAIRE |
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