Fragile X syndrome and the amygdala
| Autor: | Aparna Suvrathan, Sumantra Chattarji |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Neuronal Plasticity General Neuroscience Hippocampus Long-term potentiation medicine.disease Amygdala Models Biological Synaptic Transmission Cortex (botany) Fragile X syndrome Mice medicine.anatomical_structure nervous system Fragile X Syndrome medicine Excitatory postsynaptic potential Autism Animals Humans Psychology Neuroscience Basolateral amygdala |
| Zdroj: | Current opinion in neurobiology. 21(3) |
| ISSN: | 1873-6882 |
| Popis: | Fragile X syndrome (FXS) is the most commonly inherited form of mental impairment and autism. Current understanding of the molecular and cellular mechanisms underlying FXS symptoms is derived mainly from studies on the hippocampus and cortex. However, FXS is also associated with strong emotional symptoms, which are likely to involve changes in the amygdala. Unfortunately, the synaptic basis of amygdalar dysfunction in FXS remains largely unexplored. Here we describe recent findings from mouse models of FXS that have identified synaptic defects in the basolateral amygdala that are in many respects distinct from those reported earlier in the hippocampus. Long-term potentiation and surface expression of AMPA-receptors are impaired. Further, presynaptic defects are seen at both excitatory and inhibitory synapses. Remarkably, some of these synaptic defects in the amygdala are also amenable to pharmacological rescue. These results also underscore the need to modify the current hippocampus-centric framework to better explain FXS-related synaptic dysfunction in the amygdala. |
| Databáze: | OpenAIRE |
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