DMO-transport in human red blood cells
| Autor: | G. Michelson, K. F. Schnell, C. Albers |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
Erythrocytes Physiology Stereochemistry Diffusion Butanol Clinical Biochemistry Dimethadione Biological Transport Human physiology Hydrogen-Ion Concentration In Vitro Techniques Models Biological chemistry.chemical_compound Red blood cell medicine.anatomical_structure chemistry DIDS Permeability (electromagnetism) Physiology (medical) medicine Biophysics Humans Oxazoles Mathematics |
| Zdroj: | Pflugers Archiv : European journal of physiology. 406(6) |
| ISSN: | 0031-6768 |
| Popis: | The DMO (5,5-dimethyloxazolidine-2,4-dione) transport was studied in human red blood cells by measuring the 14C-DMO back exchange under self exchange conditions from 14C-DMO labeled cells at 0 degrees C. the unidirectional DMO-flux was linearly related to the DMO concentration up to approx. 100 mM. The unidirectional DMO-flux increases as pH is reduced. The DMO transport is not inhibited by anion transport inhibitors like DIDS, SITS, dipyridamole, phlorhizin, salicylate or butanol. A close correlation between the unidirectional DMO-flux and DMOH, the unionized form of DMO, has been observed suggesting that DMO is transported predominantly by nonionic diffusion. the permeability of DMOH is 9.5 X 10(-6) cm/s (0 degrees C) while the permeability of DMO- cannot be assessed from our data. |
| Databáze: | OpenAIRE |
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