Could gastrointestinal tumor-initiating cells originate from cell-cell fusion in vivo?
| Autor: | Ying Xiang, Wen-Qi Cai, Hong-Wu Xin, Jun-Ting Cheng, Bing-Rong Liu, Xian-Wang Wang, Ying Zhang, Shuzhong Cui, Hui-Yu Yang, Yang Zhou, Zi-Xian Feng, Ying-Ying Wang, Zi-Wen Han, Xiao-Chun Peng |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Opinion Review Gastrointestinal tumors Gastrointestinal tumor-initiating cell medicine.disease_cause Metastasis 03 medical and health sciences 0302 clinical medicine In vitro In vivo Cancer stem cell Medicine Stem cell business.industry Gastroenterology Cancer Cell-cell fusion medicine.disease 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer research Bone marrow-derived cells business Carcinogenesis |
| Zdroj: | World Journal of Gastrointestinal Oncology |
| ISSN: | 1948-5204 |
| Popis: | Tumor-initiating cells (TICs) or cancer stem cells are believed to be responsible for gastrointestinal tumor initiation, progression, metastasis, and drug resistance. It is hypothesized that gastrointestinal TICs (giTICs) might originate from cell-cell fusion. Here, we systemically evaluate the evidence that supports or opposes the hypothesis of giTIC generation from cell-cell fusion both in vitro and in vivo. We review giTICs that are capable of initiating tumors in vivo with 5000 or fewer in vivo fused cells. Under this restriction, there is currently little evidence demonstrating that giTICs originate from cell-cell fusion in vivo. However, there are many reports showing that tumor generation in vitro occurs with more than 5000 fused cells. In addition, the mechanisms of giTIC generation via cell-cell fusion are poorly understood, and thus, we propose its potential mechanisms of action. We suggest that future research should focus on giTIC origination from cell-cell fusion in vivo, isolation or enrichment of giTICs that have tumor-initiating capabilities with 5000 or less in vivo fused cells, and further clarification of the underlying mechanisms. Our review of the current advances in our understanding of giTIC origination from cell-cell fusion may have significant implications for the understanding of carcinogenesis and future cancer therapeutic strategies targeting giTICs. |
| Databáze: | OpenAIRE |
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