A Novel Mitochondria-Targeting Iron Chelator Neuroprotects Multimodally via HIF-1 Modulation Against a Mitochondrial Toxin in a Dopaminergic Cell Model of Parkinson’s Disease

Autor: Belinda Fouché, Stephanie Turner, Rebecca Gorham, Eloise J. Stephenson, Simon Gutbier, Joanna L. Elson, Olimpo García-Beltrán, Francois H. Van Der Westhuizen, Ilse S. Pienaar
Rok vydání: 2022
Předmět:
Zdroj: Molecular Neurobiology. 60:749-767
ISSN: 1559-1182
0893-7648
Popis: Coumarins are plant-derived polyphenolic compounds belonging to the benzopyrones family, possessing wide-ranging pharmaceutical applications including cytoprotection, which may translate into therapeutic potential for multiple diseases, including Parkinson's disease (PD). Here we demonstrate the neuroprotective potential of a new polyhydroxyl coumarin, N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetamide (CT51), against the mitochondrial toxin 1-methyl-4-phenylpyridinium (MPP
Databáze: OpenAIRE
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