Validation of a scoring system to establish the probability of myelodysplastic syndrome in patients with unexplained cytopenias or macrocytosis
| Autor: | Liying Zhang, Jennifer Rauw, Marciano D. Reis, Rena Buckstein, Richard A. Wells, Alden Chesney |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Pathology Myeloid Pancytopenia Anemia Macrocytosis Sensitivity and Specificity Cohort Studies Diagnosis Differential Bone Marrow hemic and lymphatic diseases Internal medicine medicine Humans Anemia Macrocytic Hydro-Lyases Aged Probability medicine.diagnostic_test business.industry Myelodysplastic syndromes Bone Marrow Examination Red blood cell distribution width Hematology Middle Aged Prognosis medicine.disease Bone marrow examination Leukemia Myeloid Acute Leukemia medicine.anatomical_structure Oncology Research Design Myelodysplastic Syndromes Female Bone marrow business |
| Zdroj: | Leukemia Research. 35:1335-1338 |
| ISSN: | 0145-2126 |
| DOI: | 10.1016/j.leukres.2011.05.001 |
| Popis: | Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell disorders primarily seen in the elderly that are characterized by ineffective hematopoiesis and a propensity to develop AML. Clinicians may be hesitant to refer older patients with unexplained cytopenias and/or macrocytosis for a bone marrow biopsy (BM), and consequently undiagnosed patients may be deprived access to effective treatments. Previously, we described factors which were independently predictive of a diagnosis of MDS at time of bone marrow: age ≥65, mean cell volume (MCV), red cell distribution width (RDW), and lactate dehydrogenase (LDH), and suggested a scoring system to calculate the post-test probability of MDS [1]. In this study we validate this scoring system in a cohort of 313 individuals who underwent bone marrow examinations for the investigation of unexplained cytopenias and or macrocytosis over a 3 year period at our institution (2006-2008). Thirty-two percent of all patients were diagnosed with MDS and 9% had suspected MDS. The post-test likelihood of a diagnosis of MDS increased from 12% when none of the four identified factors were present to 48% when 3 or more factors were present. This scoring system can be used to guide the diagnostic testing of patients presenting with unexplained cytopenias or macrocytosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect