Association of Body Mass Index with the Tuberculosis Infection: a Population-based Study among 17796 Adults in Rural China
| Autor: | Qi Jin, Lei Gao, Xinhua Wang, Jianmin Liu, Haoran Zhang, Wei Lu, Hengjing Li, Xiangwei Li, Henan Xin, Mufei Li, Liqiong Bai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Rural Population 0301 basic medicine China Tuberculosis Adolescent Cross-sectional study 030106 microbiology Population Overweight Article Body Mass Index Young Adult 03 medical and health sciences 0302 clinical medicine Prevalence medicine Humans Obesity Prospective Studies 030212 general & internal medicine education Prospective cohort study Aged education.field_of_study Multidisciplinary business.industry Mycobacterium tuberculosis Odds ratio Middle Aged Prognosis medicine.disease Cross-Sectional Studies Female medicine.symptom business Body mass index Follow-Up Studies Demography |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep41933 |
| Popis: | Body mass index (BMI) has been shown to be associated with host susceptibility to several infections. However, the link between BMI and the risk of tuberculosis (TB) infection has been sparsely studied in China and in worldwide. Based on the baseline survey of a population-based, prospective study in rural China, the association between BMI and TB infection among adults was estimated by means of cross-sectional analysis. TB infection status was tested using QuantiFERON-TB Gold In-Tube (QFT), a commercial of interferon-γ release assay (IGRA). Totally, 17796 eligible participants aged ≥18 years from 4 study sites, were included in the analysis. 21.76% (3873/17796) were observed to be QFT positive. Age and gender standardized prevalence ranged from 16.49% to 23.81% across the study sites. 42.19% study participants were obese/overweight with BMI ≥ 24.0 kg/m2. BMI ≥ 28.0 kg/m2 was observed to be independently associated with QFT positivity (adjusted odds ratio: 1.17, 95% confidence interval: 1.04–1.33). The strength of the association was found to be geographically diversity, which might be explained, at least partly, by the varied local TB epidemic status. Our results suggest that individuals with obesity might be one important target population for TB infection control in rural China. |
| Databáze: | OpenAIRE |
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