Quality of harvested autologous platelets compared with stored donor platelets for use after cardiopulmonary bypass procedures
| Autor: | Mark Crowther, R. R. Jeffrey, Isobel Ford, S. J. Urbaniak, M. Greaves |
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| Rok vydání: | 2000 |
| Předmět: |
Cardiopulmonary Bypass
P-selectin business.industry Plateletpheresis Fibrinogen binding Platelet Transfusion Hematology Flow Cytometry Platelet Activation Hemostasis Surgical Statistics Nonparametric Andrology Blood Transfusion Autologous Blood product Anesthesia Humans Medicine Platelet Platelet activation Coronary Artery Bypass Mean platelet volume business Whole blood |
| Zdroj: | British Journal of Haematology. 111:175-181 |
| ISSN: | 1365-2141 0007-1048 |
| DOI: | 10.1046/j.1365-2141.2000.02347.x |
| Popis: | Platelet dysfunction has a major contribution in bleeding after cardiopulmonary bypass (CPB) and transfusion of platelets is frequently used to secure haemostasis. Allogeneic platelets prepared for transfusion are functionally impaired. Autologous platelets harvested preoperatively require a shorter storage time before transfusion and their use also avoids the risks associated with transfusion of allogeneic blood products. For the first time, we have compared the functional quality of autologous platelets with allogeneic platelets prepared by two methods, immediately before infusion. Platelet activation was assessed by P-selectin expression and fibrinogen binding using flow cytometry. We also monitored the effects of CPB surgery and re-infusion of autologous platelets on platelet function. Autologous platelet-rich plasma (PRP) contained a significantly lower (P |
| Databáze: | OpenAIRE |
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