Impact of co-exposure of aldrin and titanium dioxide nanoparticles at biochemical and molecular levels in Zebrafish
| Autor: | Rakhi Agarwal, Saurabh Shukla, M. S. Dahiya, Reena C. Jhamtani, P. Sivaperumal |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Insecticides Health Toxicology and Mutagenesis Gene Expression 010501 environmental sciences Kidney Toxicology medicine.disease_cause 01 natural sciences Pesticide toxicity Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound Malondialdehyde medicine Animals Drug Interactions Aldrin Zebrafish 0105 earth and related environmental sciences Titanium Pharmacology Glutathione Peroxidase biology Superoxide Dismutase Chemistry Brain General Medicine Catalase Glutathione people.cause_of_death 030104 developmental biology Liver Bioaccumulation Environmental toxicology Toxicity biology.protein Biophysics Nanoparticles Lipid Peroxidation people Water Pollutants Chemical Oxidative stress |
| Zdroj: | Environmental Toxicology and Pharmacology. 58:141-155 |
| ISSN: | 1382-6689 |
| DOI: | 10.1016/j.etap.2017.12.021 |
| Popis: | Aldrin (ALD), a persistent-organic-pollutant (POP), an organochlorine-cyclodiene-pesticide is highly toxic in nature. Titanium dioxide nanoparticles (TNP) are widely used for various industrial applications. Despite the remarkable research on pesticide toxicity, the work with impact of nanoparticles on POP has been dealt with marginally. Chemicals co-exist in the environment and exhibit interactive effects. An investigation was carried out to evaluate the individual and combined effects of ALD (6 ppm) and TNP (60 ppm) exposure at sub-lethal concentration for 24 h in zebrafish. Significant reversal of lipid peroxidation level in liver and brain tissues and restoration in enhanced catalase activity in all examined tissues were observed in combined group. For other parameters, combined exposure of ALD and TNP does not show significant reversal action on ALD toxicity. Further studies are inline to understand combined effects of both to achieve significant reversal of ALD toxicity by TNP nanoparticles with threshold concentration of aldrin. |
| Databáze: | OpenAIRE |
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