EBP1 and DRBP76/NF90 binding proteins are included in the major histocompatibility complex class II RNA operon
| Autor: | Valeria Cicatiello, Luisa Cigliano, Antonella Maffei, Giuseppe Manco, Giovanna Del Pozzo, Alessandra Citro, Paolo Abrescia, Carmela Corso, Pasquale Barba, Laura Pisapia |
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| Přispěvatelé: | C., Corso, L., Pisapia, A., Citro, V., Cicatiello, P., Barba, Cigliano, Luisa, Abrescia, Paolo, A., Maffei, G., Manco, G., DEL POZZO |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Cytoplasm
mRNA operon Operon Antigen-Presenting Cells RNA-binding protein Human leukocyte antigen Biology DNA-binding protein angiogenesis Cell Line Tumor Genetics Humans RNA Messenger Nuclear protein Nuclear Factor 90 Proteins 3' Untranslated Regions class II MHC Adaptor Proteins Signal Transducing Messenger RNA Histocompatibility Antigens Class II Signal transducing adaptor protein RNA RNA-Binding Proteins Cell biology ribonucleoprotein complex Gene Expression Regulation Gene Knockdown Techniques |
| Zdroj: | Nucleic Acids Research Nucleic acids research (2011). info:cnr-pdr/source/autori:Corso C, Pisapia L, Citro A, Cicatiello V, Barba P, Cigliano L, Abrescia P, Maffei A, Manco G, Del Pozzo G/titolo:EBP1 and DRBP76%2FNF90 binding proteins are included in the Major Histocompatibility Complex Class II RNA operon/doi:/rivista:Nucleic acids research/anno:2011/pagina_da:/pagina_a:/intervallo_pagine:/volume |
| ISSN: | 1362-4962 0305-1048 |
| Popis: | Major histocompatibility complex class II mRNAs encode heterodimeric proteins involved in the presentation of exogenous antigens during an immune response. Their 3′UTRs bind a protein complex in which we identified two factors: EBP1, an ErbB3 receptor-binding protein and DRBP76, a double-stranded RNA binding nuclear protein, also known as nuclear factor 90 (NF90). Both are well-characterized regulatory factors of several mRNA molecules processing. Using either EBP1 or DRBP76/NF90-specific knockdown experiments, we established that the two proteins play a role in regulating the expression of HLA-DRA, HLA-DRB1 and HLA-DQA1 mRNAs levels. Our study represents the first indication of the existence of a functional unit that includes different transcripts involved in the adaptive immune response. We propose that the concept of ‘RNA operon’ may be suitable for our system in which MHCII mRNAs are modulated via interaction of their 3′UTR with same proteins. |
| Databáze: | OpenAIRE |
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