Oral Epithelial Cell Responses to Multispecies Microbial Biofilms
| Autor: | Karen F. Novak, Sreenatha Kirakodu, J. L. Ebersole, Rebecca Peyyala |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Microbial Consortia
Biology medicine.disease_cause Microbiology Gingivitis stomatognathic system Interleukin-1alpha medicine Humans Periodontitis General Dentistry Porphyromonas gingivalis Cell Line Transformed Fusobacterium nucleatum Interleukin-6 Streptococcus Mouth Mucosa Biofilm Streptococcus gordonii Epithelial Cells Research Reports biology.organism_classification stomatognathic diseases Biofilms Host-Pathogen Interactions Actinomyces naeslundii Cytokines medicine.symptom Bacteria |
| Zdroj: | Journal of Dental Research. 92:235-240 |
| ISSN: | 1544-0591 0022-0345 |
| Popis: | This report describes the use of a novel model of multispecies biofilms to stimulate profiles of cytokines/chemokines from oral epithelial cells that contribute to local inflammation in the periodontium. Streptococcus gordonii (Sg) /S. oralis (So) /S. sanguinis (Ss) and Sg/ Fusobacterium nucleatum (Fn) /Porphyromonas gingivalis (Pg) biofilms elicited significantly elevated levels of IL-1α and showed synergistic stimulatory activity compared with an additive effect of the 3 individual bacteria. Only the Sg/ Actinomyces naeslundii (An)/Fn multispecies biofilms elicited IL-6 levels above those of control. IL-8 was a primary response to the Sg/An/Fn biofilms, albeit the level was not enhanced compared with a predicted composite level from the monospecies challenges. These results represent some of the first data documenting alterations in profiles of oral epithelial cell responses to multispecies biofilms. |
| Databáze: | OpenAIRE |
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