Spatiotemporal persistence of multiple, diverse clades and toxins of Corynebacterium diphtheriae

Autor: Eva Heinz, Karthick Vasudevan, Thandavarayan Ramamurthy, Stephen Baker, Ankur Mutreja, Naresh Chand Sharma, Gordon Dougan, Agila Kumari Pragasam, Pradeep Haldar, Robert C. Will, Balaji Veeraraghavan, Bhabatosh Das, Lucky Sangal, Vyacheslav Melnikov, Vartul Sangal, Dhirendra Kumar
Přispěvatelé: Will, Robert C. [0000-0002-4230-5182], Kumar, Dhirendra [0000-0002-8014-2521], Das, Bhabatosh [0000-0002-2447-5380], Heinz, Eva [0000-0003-4413-3756], Melnikov, Vyacheslav [0000-0002-0825-7930], Baker, Stephen [0000-0003-1308-5755], Sangal, Vartul [0000-0002-7405-8446], Mutreja, Ankur [0000-0002-1118-8075], Apollo - University of Cambridge Repository, Will, Robert C [0000-0002-4230-5182]
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Bacterial toxins
Diphtheria Toxoid
General Physics and Astronomy
medicine.disease_cause
Bacterial evolution
Anti-Infective Agents
Diphtheria Toxin
Clade
Phylogeny
Genetics
Multidisciplinary
biology
article
Diphtheria
C500
Genomics
C700
humanities
3. Good health
Pathogens
wc_320
Science
030106 microbiology
631/326/41/2529
631/326/41/1319
qw_125
India
45/22
45/23
Microbial Sensitivity Tests
complex mixtures
Polymorphism
Single Nucleotide
General Biochemistry
Genetics and Molecular Biology
qw_805
03 medical and health sciences
Antibiotic resistance
Phylogenetics
Drug Resistance
Bacterial
medicine
Humans
Gene
631/326/41/2530
Bacterial genomics
Corynebacterium diphtheriae
45
Toxin
631/326/421
qu_500
Genetic Variation
General Chemistry
biology.organism_classification
medicine.disease
030104 developmental biology
Bacteria
Genome
Bacterial
Zdroj: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
ISSN: 2041-1723
Popis: Diphtheria is a respiratory disease caused by the bacterium Corynebacterium diphtheriae. Although the development of a toxin-based vaccine in the 1930s has allowed a high level of control over the disease, cases have increased in recent years. Here, we describe the genomic variation of 502 C. diphtheriae isolates across 16 countries and territories over 122 years. We generate a core gene phylogeny and determine the presence of antimicrobial resistance genes and variation within the tox gene of 291 tox+ isolates. Numerous, highly diverse clusters of C. diphtheriae are observed across the phylogeny, each containing isolates from multiple countries, regions and time of isolation. The number of antimicrobial resistance genes, as well as the breadth of antibiotic resistance, is substantially greater in the last decade than ever before. We identified and analysed 18 tox gene variants, with mutations estimated to be of medium to high structural impact.
Cases of diphtheria have increased in recent years. Here, the authors analyse the genomes of 502 Corynebacterium diphtheriae isolates across 16 countries and territories over 122 years, describing an increase in antimicrobial resistance genes and identifying toxin variants.
Databáze: OpenAIRE
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