Visceral adipose tissue is a better predictor than BMI in the alternative Fistula Risk Score in patients undergoing pancreatoduodenectomy
| Autor: | Claudia J. Lucassen, Jesse V. Groen, M. Hosein Aziz, Esther Bastiaannet, Bert A. Bonsing, Eva Leistra, Shirin Shahbazi Feshtali, Alexander L. Vahrmeijer, Anneke Droop, J. Sven D. Mieog |
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| Přispěvatelé: | Surgery, Nutrition and Health, APH - Aging & Later Life, APH - Health Behaviors & Chronic Diseases |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
SDG 16 - Peace
Hepatology SDG 16 - Peace Justice and Strong Institutions Gastroenterology Intra-Abdominal Fat Risk Assessment Justice and Strong Institutions Pancreaticoduodenectomy Body Mass Index Pancreatic Fistula Postoperative Complications SDG 3 - Good Health and Well-being Risk Factors Humans Retrospective Studies |
| Zdroj: | HPB, 24(10), 1679-1687. John Wiley & Sons Inc. HPB, 24(10), 1679-1687. Elsevier HPB, 24(10), 1679-1687. ELSEVIER SCI LTD Lucassen, C J, Groen, J V, Aziz, M H, Bastiaannet, E, Bonsing, B A, Leistra, E, Shahbazi Feshtali, S, Vahrmeijer, A L, Droop, A & Mieog, J S D 2022, ' Visceral adipose tissue is a better predictor than BMI in the alternative Fistula Risk Score in patients undergoing pancreatoduodenectomy ', HPB, vol. 24, no. 10, pp. 1679-1687 . https://doi.org/10.1016/j.hpb.2022.03.004 |
| ISSN: | 1477-2574 1365-182X |
| Popis: | Background: Muscle attenuation (MA) and visceral adipose tissue (VAT) have not yet been included in the currently used alternative Fistula Risk Score (a-FRS). The aim of this study was to examine the added value of these parameters as predictors of clinically relevant postoperative pancreatic fistula (CR-POPF) in the a-FRS after pancreatoduodenectomy compared to Body Mass Index (BMI). Methods: A single center retrospective cohort study was performed in patients who underwent pancreatoduodenectomy between 2009 and 2018. The a-FRS model was reproduced, MA and VAT were both combined and separately added to the model instead of BMI using logistic regression analysis. Model discrimination was assessed by ROC-curves. Results: In total, 329 patients were included of which 55 (16.7%) developed CR-POPF. The a-FRS model showed an AUC of 0.74 (95%CI: 0.68–0.80). In this model, BMI was not significantly associated with CR-POPF (p = 0.16). The MA + VAT model showed an AUC of 0.81 (95%CI: 0.75–0.86). VAT was significantly associated with CR-POPF (per cm2, OR: 1.01; 95%CI: 1.00–1.01; p < 0.001). The AUC of the MA + VAT model differed significantly from the AUC of the a-FRS model (p = 0.001). Conclusion: Visceral adipose tissue is of added value in the a-FRS compared to BMI in predicting CR-POPF in patients undergoing pancreatoduodenectomy. |
| Databáze: | OpenAIRE |
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