Heritability of myopia and its relation with GDJ2 and RASGRF1 genes in Lithuania
| Autor: | Margarita Sriubiene, Edita Kunceviciene, Ilona T. Miceikiene, Rasa Liutkeviciene, Alina Smalinskiene |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Adolescent Genotype Population Spherical equivalent Real-Time Polymerase Chain Reaction Gastroenterology Polymorphism Single Nucleotide Connexins 03 medical and health sciences Young Adult 0302 clinical medicine lcsh:Ophthalmology Internal medicine medicine Myopia Diseases in Twins Odds Ratio Humans Genetic Predisposition to Disease education Gene RASGRF1 education.field_of_study Gap junction protein business.industry ras-GRF1 Twin GJD2 Lithuania General Medicine Odds ratio Heritability Refractive Errors Ophthalmology 030104 developmental biology lcsh:RE1-994 030221 ophthalmology & optometry Female business Research Article |
| Zdroj: | BMC Ophthalmology BMC Ophthalmology, Vol 18, Iss 1, Pp 1-6 (2018) |
| ISSN: | 1471-2415 |
| Popis: | Background This study aimed to assess heritability of myopia in Lithuania and evaluate both genes GJD2 (Gap Junction Protein, Delta 2) and RASGRF1 (RAS protein-specific guanine nucleotide-releasing factor 1) relation with myopia. Methods In this study Lithuanian twin population aged between 18 and 40 (n = 460) were examined. Single-nucleotide polymorphisms of the RASGRF1 (rs8027411) and GJD2 (rs634990) genes were assessed by real-time polymerase chain reaction method. Results Intrapair correlations for spherical equivalent in all twin pairs were significantly higher in MZ twin pairs r = 0.539 (p 0.05, 95% CI -0.215-0.381) and in DZ twin pairs r = − 0.220 (p > 0.05, 95% CI -0.587-0.222). The odds ratio (95% CI) were 2.7 (1.018–7.460) for combinations of genotypes of rs634990 CC and rs8027411 GT (p = 0.046). Conclusions Our studies have shown that the heritability of myopia makes 67.2% in Lithuania. Persons with combinations of genotypes rs634990 CC and rs8027411 GT have 2.7 times higher odds to have myopia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink