Protective action of honokiol, administered orally, against oxidative stress in brain of mice challenged with NMDA
| Autor: | U J Youn, Long Shuang Huang, H S Cui, Byoung-Mog Kwon, D E Sok, KiHwan Bae, Ji-Ae Shin |
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| Rok vydání: | 2006 |
| Předmět: |
Male
N-Methylaspartate Pharmaceutical Science Administration Oral Pharmacology medicine.disease_cause Neuroprotection Lignans Lipid peroxidation chemistry.chemical_compound Mice Oral administration Drug Discovery medicine TBARS Animals Mice Inbred ICR Dose-Response Relationship Drug Chemistry Plant Extracts Biphenyl Compounds Neurotoxicity Brain Glutathione medicine.disease Oxidative Stress Neuroprotective Agents Complementary and alternative medicine Magnolia Anesthesia Plant Bark Molecular Medicine NMDA receptor Oxidative stress Injections Intraperitoneal Phytotherapy |
| Zdroj: | Phytomedicine : international journal of phytotherapy and phytopharmacology. 14(10) |
| ISSN: | 0944-7113 |
| Popis: | Neuroprotective effect of honokiol (HK), orally administered, on oxidative damage in the brain of mice challenged with N-methyl-d-aspartic acid (NMDA) was examined. HK (1-100 mg/kg) was administered to Institute of Cancer Research (ICR) male mice through a gavage for 3 days consecutively, and on the third day, NMDA (150 mg/kg) was intraperitoneally (i.p.) administered. Administration of NMDA, causing a lethality of approximately 60%, resulted in a significant decrease of total glutathione (GSH) level and increase of thiobarbituric acid-reactive substances (TBARS) value in brain tissue. Meanwhile, oral administration of HK (> or = 3 mg/kg) for 3 days reduced the lethality (60%) in NMDA-treated group to 10% level, and alleviated the behavioral signs of NMDA neurotoxicity. Moreover, HK pretreatment restored the levels of total GSH and TBARS in the brain tissue to control levels (p |
| Databáze: | OpenAIRE |
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