High-dose-rate brachytherapy alone given as two or one fraction to patients for locally advanced prostate cancer: Acute toxicity

Autor: Roberto Alonzi, Peter Hoskin, Ana M. Rojas, Peter Ostler, Linda Bryant, Robert Hughes, Gerry Lowe
Rok vydání: 2014
Předmět:
Urologic Diseases
Male
medicine.medical_specialty
Urologic Diseases/etiology
Gastrointestinal Diseases
Urethra/radiation effects
medicine.medical_treatment
Brachytherapy
Urology
Brachytherapy/adverse effects
Prostate cancer
Urethra
Prostate
Radiation Injuries/etiology
medicine
Humans
Radiology
Nuclear Medicine and imaging
Radiation Injuries
Adverse effect
Aged
Manchester Cancer Research Centre
business.industry
ResearchInstitutes_Networks_Beacons/mcrc
Rectum
Prostatic Neoplasms
Dose-Response Relationship
Radiation
Hematology
Middle Aged
Iridium Radioisotopes
medicine.disease
Iridium Radioisotopes/administration & dosage
Acute toxicity
High-Dose Rate Brachytherapy
Prostatic Neoplasms/radiotherapy
Surgery
Radiation therapy
medicine.anatomical_structure
Oncology
Gastrointestinal Diseases/etiology
International Prostate Symptom Score
Rectum/radiation effects
business
Zdroj: Hoskin, P, Rojas, A, Ostler, P, Hughes, R, Alonzi, R, Lowe, G & Bryant, L 2014, ' High-dose-rate brachytherapy alone given as two or one fraction to patients for locally advanced prostate cancer : acute toxicity ', Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, vol. 110, no. 2, pp. 268-71 . https://doi.org/10.1016/j.radonc.2013.09.025
ISSN: 0167-8140
Popis: BACKGROUND: To evaluate early urinary (GU) and gastrointestinal (GI) adverse events (AEs) after two or one fraction of high-dose rate brachytherapy (HDR-BT) in advanced prostate cancer.PATIENTS AND METHODS: 165 patients were treated with 2 × 13 Gy (n=115), or a single dose of 19 Gy (n=24) or 20 Gy (n=26) HDR-BT. Early AEs were assessed using the RTOG scoring system and the International Prostate Symptom Score (IPSS).RESULTS: Week-2 prevalence of severe IPSS symptoms was higher after 20 Gy than after 26 or 19 Gy but by 12 weeks all groups were at pre-treatment levels or less. Grade-3 GU toxicity was observed ≤9% of patients. No Grade 4 GU and no Grade 3 or 4 GI complications were observed. However, there was a significant increase in catheter use in the first 12 weeks after implant after 19 and 20 Gy compared with 2 × 13 Gy.CONCLUSION: Single dose HDR-BT is feasible with acceptable levels of acute complications; tolerance may have been reached with the single 19 Gy schedule.
Databáze: OpenAIRE
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