Effect of Pulmonary Surfactant on Antimicrobial Activity In Vitro
| Autor: | Markus Zeitlinger, Sabine Strommer, Mohammad Manafi, Richard Schwameis, Z. Erdogan-Yildirim, Robert Sauermann |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Staphylococcus aureus
Swine medicine.drug_class Moxifloxacin Antibiotics Minocycline Microbial Sensitivity Tests Tigecycline Microbiology chemistry.chemical_compound Anti-Infective Agents Daptomycin Acetamides polycyclic compounds medicine Animals heterocyclic compounds Pharmacology (medical) Oxazolidinones Pharmacology Aza Compounds Colistin business.industry Doripenem Linezolid Pulmonary Surfactants biochemical phenomena metabolism and nutrition bacterial infections and mycoses Antimicrobial Infectious Diseases Carbapenems chemistry Quinolines lipids (amino acids peptides and proteins) business Fluoroquinolones medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 57:5151-5154 |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | Time-kill curve experiments were performed with linezolid, doripenem, tigecycline, moxifloxacin, and daptomycin against Staphylococcus aureus and with colistin, moxifloxacin, and doripenem against Pseudomonas aeruginosa to evaluate the effect of porcine pulmonary surfactant on antimicrobial activity. Pulmonary surfactant significantly impaired the activities of moxifloxacin and colistin. When antibiotics are being developed for respiratory tract infections, the method described here might be used to preliminarily quantify the effect of pulmonary surfactant on antimicrobial activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|