Whole grain consumption and risk of colorectal cancer: a population-based cohort of 60 000 women
| Autor: | Alicja Wolk, Leif Bergkvist, Susanna C. Larsson, Edward Giovannucci |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Dietary Fiber Cancer Research medicine.medical_specialty Epidemiology Colorectal cancer Population Rate ratio Lower risk Gastroenterology Cohort Studies Risk Factors Internal medicine medicine Humans Prospective Studies Risk factor Prospective cohort study education Aged education.field_of_study Rectal Neoplasms business.industry Secale dietary fibre Middle Aged medicine.disease Diet Cancer registry rye whole grains colon cancer Oncology Colonic Neoplasms Cohort Female Colorectal Neoplasms business Follow-Up Studies |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | We examined prospectively the association between whole grain consumption and colorectal cancer risk in the population-based Swedish Mammography Cohort. A total of 61,433 women completed a food-frequency questionnaire at baseline (1987-1990) and, through linkage with the Swedish Cancer Registry, 805 incident cases of colorectal cancer were identified during a mean follow-up of 14.8 years. High consumption of whole grains was associated with a lower risk of colon cancer, but not of rectal cancer. The multivariate rate ratio (RR) of colon cancer for the top category of whole grain consumption (or = 4.5 servings day(-1)) compared with the bottom category (1.5 servings day(-1)) was 0.67 (95% confidence interval (CI), 0.47-0.96; P-value for trend=0.06). The corresponding RR after excluding cases occurring within the first 2 years of follow-up was 0.65 (95% CI, 0.45-0.94; P-value for trend=0.04). Our findings suggest that high consumption of whole grains may decrease the risk of colon cancer in women. |
| Databáze: | OpenAIRE |
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